Pyew is a (command line) python tool like radare and *iew
oriented, mainly, to analyze malware. It does have support for
hexadecimal viewing, disassembly (Intel 16, 32 and 64 bits), PE and ELF
file formats (it does code analysis the right way), following direct
call/jmp instructions, OLE2 format, PDF format (limited) and more. It
also supports plugins to add more features to the tool.
DeepToad is an open source (LGPL) tool to generate fuzzy hashes and compare similar files. It can be used, in example, to clusterize malware samples. DeepToad is very similar to ssdeep and nilsimsa.
Zero wine is an open
source (GPL v2) research project to dynamically analyze the behavior of
malware. Zero wine just runs the malware using WINE in a safe virtual
sandbox (in an isolated environment) collecting information about the
APIs called by the program. The tool is distributed as a prebuilt QEmu virtual machine (or in source code form).